ATR anticorps (AA 426-430)

N° du produit ABIN363072

L’anticorps Lapin Polyclonal anti-ATR a été validé pour IHC. Il convient pour détecter ATR dans des échantillons de Humain.

Aperçu rapide pour ATR anticorps (AA 426-430) (ABIN363072)

Antigène: ATR (ATR serine/threonine kinase (ATR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATR est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-ATR anticorps

Épitope: AA 426-430

Specificité: The antibody detects endogenous level of total ATR protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.

Immunogène: Peptide sequence around AA 426-430 (G-I-S-P-K) derived from Human ATR. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry: 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur ATR

Antigène: ATR (ATR serine/threonine kinase (ATR))

Autre désignation: ATR

Sujet: ATR encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

Poids moléculaire: 250 kDa

NCBI Accession: NP_001175

UniProt: Q13535

Pathways: Positive Regulation of Response to DNA Damage Stimulus